Coat Slow Cooker:
Coat the interior of a 6-quart slow cooker with a thin layer of non-stick spray.Arrange Beef and Potatoes:
Arrange the beef cubes on one side of the cooker and the potatoes on the opposite side, keeping them separate.Season Meat and Potatoes:
Evenly dust both the meat and potatoes with onion powder, garlic powder, and seasoned salt. Toss gently to distribute, maintaining the separation.Add Garlic and Butter:
Scatter the minced garlic over the surface, then dot with butter pieces across the meat and potatoes.Cook on Low:
Cover and cook on LOW for 6 hours, until the beef is fork-tender and the potatoes are soft.Stir and Serve:
Once done, stir lightly to blend the juices, then serve the beef and potatoes with the buttery garlic sauce drizzled on top.