Preheat Oven and Prep Pan:
Heat oven to 375°F (190°C). Prepare a muffin pan by lining cups with paper liners or greasing them lightly.Whisk Dry Ingredients:
In a big bowl, combine 2 cups flour, poppy seeds, baking powder, baking soda, and salt with a whisk. Put aside.Mix Wet Ingredients:
In another bowl, work lemon zest into ¾ cup sugar until it smells fragrant. Pour in melted butter, eggs, vanilla, buttermilk, and ¼ cup lemon juice; whisk until everything is mixed well.Combine Wet and Dry:
Slowly incorporate the wet mixture into the dry mixture, folding carefully until just combined. Avoid overmixing.Make Streusel Topping:
If making streusel: In a small bowl, stir together ¼ cup flour and brown sugar. Work in cold butter until the mixture is crumbly.Fill Muffin Cups:
Divide batter among the prepared muffin cups, filling them to about ¾ full. If desired, sprinkle streusel on top.